About Diabetes

About Diabetes

With the improvement of living standards, the prevalence of diabetes is on the rise all over the world. It has become another non communicable chronic disease that seriously endangers human health. The prevention, diagnosis and treatment of diabetes and its complications are still the research focus of clinical medicine and biomedicine. As a dedicated CRO company, Ace Metabolism offers a full range of research and therapy services related to diabetes.

What is Diabetes

Diabetes mellitus is a chronic, systemic, metabolic disease caused by the long-term combination of genetic factors and environmental factors, characterized by increased plasma glucose levels, mainly due to insufficient insulin secretion or dysfunction in the body (insulin resistance). The disorder of sugar, fat and protein metabolism caused can affect normal physiological activities and manifest as a variety of acute and chronic complications.

Fig 2. Glucose-Stimulated Insulin Secretion from Pancreatic beta-Cells Glucose-Stimulated Insulin Secretion from Pancreatic β-Cells (Mourad, F.; et al. Trends in Cell Biology. 2016)

Classification of Diabetes

Diabetes is a chronic (long-lasting) health condition that affects how your body turns food into energy. When blood sugar goes up, it signals the pancreas to release insulin. The main types of diabetes include type 1 diabetes mellitus (T1DM), type 2 diabetes mellitus (T2DM), gestational diabetes (diabetes while pregnant) and other special types of diabetes (the diabetes caused by all causes except T1DM, T2DM and GDM).

Complications of Diabetes

All forms of diabetes increase the risk of long-term complications. The serious harm of diabetes is to cause many complications, including infectious diseases, atherosclerosis, microvascular disease, neurological complications and so on. The number of diabetes related deaths worldwide is about 1.5 million per year. It can be seen that diabetes is an area worthy of in-depth research, and more pathological research and therapy development are still needed.

Fig 3. Complications of diabetes

Advances in Diabetes Therapies

Recombinant insulin and insulin analogs are the main drugs for clinical treatment of diabetes. In addition, there are new treatment methods such as islet/pancreas transplantation, cell and gene therapy, but the technical methods are cumbersome and need to solve problems such as immune rejection.

  • Distribution of R&D Companies
    The global research and development of diabetes treatment drugs is mainly dominated by multinational pharmaceutical companies. They are mainly Novo Nordisk, Eli Lilly, Medtronic, Sanofi, Roche, Johnson & Johnson, Korea INFOPIA, Abbott, Panasonic Healthcare, France Biotech company ADOCIA, etc.
  • R&D Trends
    There are nearly 3,000 diabetes treatment drugs in all stages of global research and development (including under development, suspension, withdrawal, and termination), of which about 1,500 are for T2DM and about 400 are for T1DM. And a small number of drugs are used for the treatment of special types of diabetes, such as gestational diabetes, latent autoimmune adult diabetes, etc.
  • The Drugs in Clinical Research
    In addition to hypoglycemic drugs such as metformin, which are already widely used in treatment, the field of diabetes research continues to explore therapies. Recombinant insulin and insulin analogs are the main drugs for clinical treatment of diabetes. There are some immunotherapy drugs in clinical research for diabetes.
Monoclonal antibodies Anti-inflammatory Tolerance inducer Insulin secretagogues β-cell protective agent Treg inducers
Anti-CD3 Anti-IL-1 GAD65 GLP-1 analogs Polyamine IL-2
Anti-CD20 IL-1 antagonist Insulin DPP-IV inhibitor EGF IL-10
ATG/ATS HDAC inhibitor HSP60 Exenatide GLP-1/ agonist TGF-β
CTLA-4 DNT AAT GM-CSF
CTLA4-Ig Anti-TNF-α GAD
PPI Proinsulin

In addition, there are 9 stem cell products that have entered the clinic, and the highest R&D stage is in Phase 2 clinical trials.

Names Research company Highest R&D stage
VX-880 (formerly STx-02) Vertex Pharmaceuticals Inc Phase 2 Clinical
ProTrans NextCell Pharma AB Phase 2 Clinical
MPC-300-IV Mesoblast Ltd Phase 2 Clinical
GXIPC-1 Vinmec Research Institute of Stem Cell and Gene Technology Phase 2 Clinical
PEC-Direct ViaCyte Inc Phase 2 Clinical
PEC-EnCap ViaCyte Inc Phase 2 Clinical
Allogeneic umbilical cord-derived mesenchymal stem cell therapy Medical university of South Carolina Phase 1 Clinical
Allogeneic human mesenchymal stem cells (aging frailty/Alzheimer's disease/metabolic syndrome/hypoplastic left heart syndrome) Longeveron LLC Phase 2 Clinical

Accelerate Diabetes Therapy Development

Diabetes is an area worthy of further study, Ace Metabolism provides diabetes-related services and products to accelerate your research. Mainly focus on preclinical services, including diabetes pathology research and new drug development, cell and gene therapy research, etc.

Fig 4. Specialized Services

Specialized Services

As the preclinical research organization exclusively focused on diabetes, Ace Metabolism has been involved in the development of relevant classes of therapy and glucose-lowering drugs, including cell therapy, gene therapy, new insulin analogs, drug development process of diabetes, etc.

Fig 5. System Services

System Services

Diabetes is a field worthy of in-depth research. Ace Metabolism provides research programs and technical services from pathological research to preclinical. providing our clients an advantage in a competitive landscape for novel and biosimilar medicines and therapy for diabetes.

Fig 6. Comprehensive Products

Comprehensive Products

Whether you are performing studies on new or modified medications, insulin alternatives or treatments about diabetes, Ace Metabolism can support you the comprehensive products including mouse model, assay kits, antibodies, cell line, proteins and peptides, inhibitor and activator, etc.

Our Advantages

Professional Team

Professional Team

Time-saving

Time-saving

One-stop Service

One-stop Service

High Reputation

High Reputation

Ace Metabolism guarantees to deliver our products and results on time. If you are interested in discussing how to get started with your study, please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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