Human SIRT6 knockout A549 cell line

Human SIRT6 knockout A549 cell line

Cat. No.: DCL-001049

Size: 1 × 106 cells/vial Size: Customer Size
Product Information
Parental A549
Organism Human
Tissue Lung
Target Name SIRT6
Cell Type Epithelial cells
Gender Male
UniProt No. Q8N6T7
Gene ID 51548
Gene Description NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
Format Frozen
Growth Properties Adherent
Shipping & Storage
Shipping Cryopreserved on dry ice.
Storage Instructions Store in liquid nitrogen.
Storage Buffer/Media 8.7% Dimethylsulfoxide, 2% Cellulose, methyl ether
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