Human TSC2 (Tuberin) knockout A549 cell line

Human TSC2 (Tuberin) knockout A549 cell line

Cat. No.: DCL-001027

Size: 1 × 106 cells/vial Size: Customer Size
Product Information
Parental A549
Organism Human
Tissue Lung
Target Name TSC2
Cell Type Epithelial cells
Gender Male
UniProt No. P49815
Gene ID 7249
Gene Description In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Format Frozen
Growth Properties Adherent
Shipping & Storage
Shipping Cryopreserved on dry ice.
Storage Instructions Store in liquid nitrogen.
Storage Buffer/Media 8.7% Dimethylsulfoxide, 2% Cellulose, methyl ether
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