Iron-Deficiency Anemia Research Service
Iron deficiency anemia occurs when the balance of iron intake, iron stores and body iron losses are not sufficient to fully support red blood cell production. Under this case condition, iron metabolism related pathways and protein expression are altered. Ace Therapeutics offers a wide range of research services related to iron deficiency anemia to help our clients with related drug development and pathology studies.
Physiological Mechanisms of Iron Deficiency Anemia
Iron Deficiency Anemia, IDA
The concentration of Hepc in serum and urine of patients with simple iron deficiency anemia is significantly lower, and sometimes even undetectable, mainly due to the inhibitory effect of iron deficiency and erythropoiesis on Hepc. Therefore, serum Hepc level can be used as one of the screening indicators for blood donation.
Iron-refractory Iron Deficiency Anemia, RIDA
IRIDA is a hereditary microcytic hypochromic anemia in which oral iron supplementation is ineffective and only parenteral iron supplementation is partially effective. The manifestations of IRIDA are the opposite of those of juvenile hemochromatosis caused by Hepc mutations. Recent studies suggest that IRIDA is a genetic disorder caused by excessive synthesis of Hepc due to mutations in the Hepc inhibitor TMPRSS6.
Role of hepcidin in the homeostasis of iron[1].
Diagnosis of Iron Deficiency Anemia
Iron deficiency is the most common nutritional disorder worldwide and accounts for approximately one-half of anemia cases. The diagnosis of iron deficiency anemia is confirmed by the findings of low iron stores and a hemoglobin level two standard deviations below normal.
When conducting iron deficiency anemia studies, the following tests may often be performed in order to make an accurate diagnosis in experimental animals.
- Hematology Detection
Hemoglobin and red blood cells are reduced. In mild anemia, red blood cell morphology is not significantly abnormal, and in severe cases, red blood cells may be ring-shaped. - Myelogram
Active hematopoiesis, but small red blood cell volume and enlarged empty stained areas in the red blood cells suggest microcytic hypochromic anemia. - Iron Staining Detection
Extracellular iron was significantly reduced, and intracellular iron was also reduced in the more severe cases of anemia.
Our Services
Ace Therapeutics has been dedicated to iron metabolism related disease research for many years and has a complete protein assay platform and equipment to provide diverse iron deficiency anemia research solutions according to the different needs of our clients. We will customize our technical solutions to meet the specific needs of our clients to solve all the problems found in their research on this disease.
- Iron Deficiency Anemia Animal Model Construction
We establish animal models of iron deficiency anemia through low iron diets supplemented by regular bloodletting, and regularly observe hemoglobin content, red blood cell count, hematocrit, and measure serum iron, serum ferritin, ferritin saturation, total iron binding capacity, etc. to help our clients study the mechanism related to iron deficiency anemia. - Iron Metabolism Detection in Iron Deficiency Anemia
We offer a wide range of iron metabolism assays and testing services to help our clients investigate the relationship and potential mechanisms of iron metabolism and iron deficiency anemia, laying the foundation for subsequent drug development and treatment. - Serum Iron Level
- Serum Total Iron Binding Capacity
- Transferrin Saturation
- Serum Ferritin
- Soluble Transferrin Receptor
- sTfR-F Index
- Camaschella, et al. New insights into iron deficiency and iron deficiency anemia[J]. Blood Reviews, 2017.
Why Choose US?
Ace Therapeutics has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related diseases research services. If you have any needs, please contact us.
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