T2DM Biomarker Development Service

T2DM Biomarker Development Service

T2DM is characterized by impaired glucose metabolism and insulin resistance, coupled with dysregulation of multiple biologic pathways. Accurate prediction and identification using biomarkers will be useful for T2DM prevention. As a dedicated CRO company, Ace Metabolism can provide researchers engaged in biomarker development of diabetes with more efficient function analysis.

Genetic Biomarkers of T2DM

In T2DM over 400 genetic variants have been found, and each of them has only a moderate or small effect on the risk of T2DM. These genetic variants influence multiple processes in tissues and cells, including β-cells (islet development, islet senescence, islet function), adipocytes, skeletal muscle, liver, and other tissues.

There are many candidate genes identified such as TCF7L2 gene, KCNQ1 gene, PPAR-γ gene, MODY gene et al. The TCF7L2 gene can affect glucagon-like pep-tide1 (GLP-1) levels, and the GLP-1 has stimulating effects both on insulin secretion and on β-cells growth.

  • FGF21
Fibroblast growth factor 21 (FGF21) is a secreted secretion that can regulate glucose and lipid metabolism. Its biological activity mainly involves lowering blood glucose and improving blood lipid. It promotes glycogen synthesis, controls insulin action in the liver and maintains glucose homeostasis by activating insulin signaling pathways in the liver and primary hepatocytes.
  • GLP-1
Glucagon like peptide-1 (GLP-1) is a peptide hormone, mainly secreted by endocrine cells of small intestine in response to nutritional load, and has a variety of biological effects. On the one hand, GLP-1 acts on islet β-cells in the pancreas, promoting insulin secretion and at the same time promoting the proliferation and differentiation of islet β-cells. On the other hand, it can also act on islet α-cells to reduce postprandial glucagon secretion, reduce hepatic glycogen breakdown, lower postprandial blood sugar.
  • PPAR
The peroxisome proliferator-activated receptor (PPAR) gene belongs to the steroid/thyroid/retinoic acid receptor superfamily and plays an important role in controlling fat storage and catabolism.
  • Insulin
Insulin is secreted by pancreatic β-cells and is mainly used to lower blood sugar and promote the synthesis of glycogen, fat and protein. Insulin gene mutation can lead to the development of diabetes.
  • Other genes
In T2DM over 400 genetic variants have been found, and each of them has only a moderate or small effect on the risk of T2DM. There are many candidate genes identified such as KCNQ1 gene, MODY gene, KCNJ11 gene, Calpain-10 gene, ENPP1 gene, and ADIPOR2 gene et al.

Non-genetic Biomarkers of T2DM

Metabolites can be identified as biomarkers that may be useful for the diagnosis or treatment of diabetes. For example, amino acids have been proposed to be useful diagnostic biomarkers because the metabolism of amino acids is considerably altered in pre-diabetes and continue to vary over the course of T2DM progression. Metabolites, MicroRNA or other biomolecules for T2DM to complement traditional biomarkers such as HbA1c and blood glucose.

  • Metabolomics Biomarkers
    Lipid metabolism, glucose metabolism and other metabolic abnormalities are closely related to the occurrence and development of T2DM. The content of amino acids and their derivatives is significantly related to the occurrence of diabetes. Among all the metabolites, mannose had the strongest association.
  • Circulating MicroRNAs
    The free nucleic acids can be detected β-cell death. The most important is MicroRNA (miRNA). The miR-375 may serve as a potential marker for islet β-cell death and diabetes prediction.

Identification of Islets of Langerhans Using Autofluorescence, Snapshot of Laser Capture Microdissection IsolationIdentification of Islets of Langerhans Using Autofluorescence, Snapshot of Laser Capture Microdissection Isolation (Barovic, M.; et al. Molecular metabolism, 2019)

Our Services

Effective biomarkers are of great significance for early prediction of T2DM. Ace Metabolism has the expertise, scale and instruments to provide the biomarker development services. Our services include but not limited to the followings.

Genetic Biomarkers Development

Genetic Biomarkers Development

Discovering candidate genes and mutant types of known pathogenic gene related to T2DM.

Non-genetic Biomarkers Development

Non-genetic Biomarkers Development

  • Metabolomics Biomarker Development
  • Circulating Biomarker Development

Features of Our Services

Highly CustomizableHighly Customizable

One-stop ServicesOne-stop Services

High QualitysHigh Quality

Professional TeamProfessional Team

Ace Metabolism offers cost-effect and high-quality research services related to T2DM biomarker development for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

Reference

  1. Barovic, M.; et al. Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes. Molecular metabolism. 2019, 27, S1-S6.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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