T2DM Modeling Service

T2DM Modeling Service

Diabetes is a chronic metabolic disease characterized by high blood sugar and is difficult to cure and generally requires lifelong medication. Disease models can be used as suitable research tools for diabetes. Ace Metabolism can provide modeling services of T2DM to accelerate customer research progress.

Overview of T2DM

Type 2 diabetes mellitus (T2DM) accounts for about 90% of all diabetic patients, and T2DM is mainly linked to insulin resistance. Obese individuals contain more adipose tissues, relating to the higher secretion of hormones and other substances that may increase the fluctuation of insulin sensitivity.

Fig 2. Interactions between the Environment, Epigenome, and Obesity and T2DMInteractions between the Environment, Epigenome, and Obesity and T2DM (Charlotte, L. and Tina, R. Cell Metabolism. 2019)

Advances in T2DM research

T2DM is more common in older adults, but a significant increase in the prevalence of obesity among children has led to more cases of T2DM in younger people. Even with currently available therapies, such as insulin injections, oral hypoglycemic agents, etc. However, the safety and stability of cell and gene therapies, antibody therapies still need further validation.

Fig 3. Principle of STZ Destruction of Pancreatic Islet beta-CellsPrinciple of STZ Destruction of Pancreatic Islet β-Cells (Wu, J. and Yan, L. J. Diabetes, Metabolic Syndrome and Obesity. 2015)

T2DM Models

T2DM is characterized by insulin resistance and the inability of the beta cell to sufficiently compensate. Therefore, animal models of T2DM tend to include models of insulin resistance and/or models of β-cell failure.

  • Mouse Models
    Obese models and genetically induced models are the most common mouse models of T2DM. As T2DM is closely linked to obesity, most of the current animal models of T2DM are obese.
  • Model Description
    Ob/ob Mouse Model The model is homozygous for a mutation in leptin and develop obesity, hyperphagia, glucose intolerance, insulin resistance and transient hyperglycemia.
    Db/db Mouse Model The model is monogenic, insulin-resistant model, and due to a spontaneous mutation in the leptin receptor.
    KK-Ay Mouse Model KK-Ay mice develop impaired glucose tolerance and insulin resistance, and fasting hyperglycemia.
    DIO Mice The models develop severe obesity, increased glucose intolerance, moderate insulin resistance and elevated glucose levels.
    NZO Mouse NZO mouse is a polygenic model of obesity, created by selective breeding.
    ZDF Rat These rats are less obese but have more severe insulin resistance, which due to increased apoptosis levels in the beta cells.
    OLETF Rat The rat is derived from a spontaneously diabetic rat.
    TallyHo Mouse It is a naturally occurring model of obesity and T2DM derived from selective breeding of mice.
  • Non-rodent Models
    Larger animals have also been utilized in T2DM research. T2DM in cats resembles the human condition in several aspects, including clinical, physiological and pathological aspects. Cats are one of the few species other than humans and macaques that form amyloid in islets, making them a good model for studying islet amyloidosis.

Our Services

The construction of diabetes models can better simulate the development of human diabetes. Ace Metabolism providing modeling service which can be customized by customer needs. Our services include but not limited to the followings.

Fig 4. Induced Diabetes Model

Types of Diabetes Models

  • Culture Cell Models
  • Non-human Primate Models
  • Mouse, Rat, Rabbit, Guinea Pig Models
  • Other Animal Model (Cat, Zebrafish, Drosophila, C. elegans, et al.)
Fig 5. Genetically Modified Diabetes Model

Genetically Modified Diabetes Models

  • Knock-out (Large Deletion)
  • Knock-in (Point Mutation, Large Insertion)

Features of Our Services

Highly CustomizableHighly Customizable

One-stop ServicesOne-stop Services

High QualitysHigh Quality

Professional TeamProfessional Team

Ace Metabolism offers cost-effect and high-quality research services for our clients worldwide. In addition, we offer a variety of mouse models and cell lines for diabetes research. Please feel free to contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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