Iron Metabolism-related Neurodegenerative Disease Service
Iron homeostasis is required to maintain normal physiological brain function, and dysregulation of iron homeostasis can cause neurotoxicity through different mechanisms, which in turn can lead to neurodegenerative diseases. Ace Therapeutics offers a wide range of research services in neurodegenerative diseases related to iron metabolism to assist our clients with related drug development and pathology studies.
Neurodegenerative Mechanisms Related to Iron
In brain cells, excess iron can induce oxidative stress through the production of reactive oxygen species (ROS), which can damage DNA and mitochondrial DNA. also protein aggregation involved in neurodegenerative diseases (α-synuclein 70 and hyperphosphorylated tau proteins) has been shown in vitro to be triggered by elevated concentrations of trivalent iron. Neurodegeneration due to ferroptosis can lead to apoptosis and iron death, a form of iron-specific non-apoptotic cell death.
Brain iron metabolism[1].
Iron Metabolism in Neurodegenerative Diseases
A large body of evidence suggests that abnormal accumulation of iron in the brain is associated with various neurodegenerative diseases such as Huntington's disease, Alzheimer's disease, Parkinson's disease, and Friedreich's ataxia. However, it is not clear how irregular iron status contributes to the development of neuronal diseases.
| Alzheimer's Disease | Defective homeostasis of redox-active metal iron may contribute to the neuropathology of Alzheimer's disease. High concentrations of iron are present in insoluble amyloid plaques and in the neurogenic fiber tangles characteristic of Alzheimer's disease. The accumulation of iron may deprive other brain tissues of these essential metals, leading to abnormal neuronal function. |
| Parkinson's Disease | Studies have shown that patients with Parkinson's disease have increased concentrations of total iron in the substantia nigra, while the concentration of iron in these areas increases with the severity of the disease. The high concentrations of iron detected in the substantia nigra of patients with Parkinson's disease may exceed the iron buffering capacity of complexes such as neuromelanin and ferritin, and may induce neurotoxicity. |
| Multiple Sclerosis | Increased iron concentration occurs in specific brain regions in multiple sclerosis, most prominently in deep gray matter structures, which usually manifest bilaterally. In the white matter, iron deposits are usually located at sites of inflammation associated with blood vessels. Iron concentrations in many deep gray matter structures increase as multiple sclerosis progresses. |
| Huntington's Disease | Alterations in brain iron metabolism with increased iron accumulation were identified by MRI in the striata of patients with Huntington's disease and in particular the basal ganglia. |
Our Services
Ace Therapeutics has been working on iron homeostasis related diseases for many years and has a complete protein assay platform and equipment to provide diverse solutions for neurodegenerative diseases research according to the different needs of our clients. We will customize our technical solutions to meet the specific needs of our customers to solve all the problems found in their research on this disease.
- MR Quantification of Brain Iron Deposition
With our high-end imaging platform, we offer our clients non-invasive, radiation-free magnetic resonance imaging (MRI) imaging techniques that offer unparalleled advantages in quantitative measurements of iron deposition to help them study disorders of iron homeostasis in neurodegenerative diseases. - Iron Metabolism Detection in Neurodegenerative Diseases
We offer a wide range of iron metabolism proteins (LfR, p97,CP, DMT1, IRP, HO-1, SDR2, etc.) assays and assays to help our clients study the relationship and potential mechanisms of iron metabolism with neurodegenerative diseases and lay the foundation for subsequent drug development and treatment. - Brain Ferritin Gene Assay
Mutations in the brain ferritin gene usually cause neuroferritinopathy. With our high-end technology platform, we provide our clients with ferritin mutation testing services to help them study iron metabolism related diseases more deeply and develop therapies and drugs.
Why Choose US?
Ace Therapeutics has a professional team and advanced equipment, and the whole process is operated by experienced technicians to provide our customers with iron metabolism related diseases research services. If you have any needs, please contact us.
Reference
- Ward R J, et al. The role of iron in brain ageing and neurodegenerative disorders[J]. The Lancet Neurology, 2014, 13(10): 1045-1060.