Recombinant Human AGRP Protein (His tag)
Size: 50 µg
Size: 100 µg
Size: Costomer Size
| Product Overview |
|
Species
|
Human |
|
Expression System
|
Escherichia coli |
|
Format
|
Liquid |
|
Purity
|
≥ 98% by NMR |
|
Nature
|
Recombinant |
| Target Information |
|
Gene Name
|
AGRP |
|
UniProt No.
|
O00253 |
|
Gene ID
|
181 |
|
Molecular Weight
|
15 kDa including tags |
|
Alternative Names
|
Agouti related neuropeptide; Agouti Related Protein Homolog; Agouti-related protein; Agrp; AGRP_HUMAN; AGRT; ART; ASIP2 |
|
Function
|
Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R. |
|
Involvement In Disease
|
Genetic variations in AGRP may be a cause of obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. |
|
Cellular Localization
|
Secreted. Golgi apparatus lumen. |
|
Protein Length
|
Full length protein |
|
Sequence
|
MGSSHHHHHHSSGLVPRGSHMGSHMAQMGLAPMEGIRRPDQALLPELPGL GLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCL GQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT,Contains 1 agouti domain. |
| Shipping & Storage |
|
Shipping
|
Shipped on dry ice. |
|
Storage
|
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. |
All of our services and products
are intended for preclinical research use only and cannot be used to diagnose, treat or manage
patients.
