T1DM Therapy Development Service

T1DM Therapy Development Service

The destruction of insulin-producing β-cells is the main pathophysiological feature of T1DM. Cell and gene therapy has always been thought to be able to recover eventually β-cell function, the ultimate means to cure diabetes. Ace Metabolism can provide researchers engaged in cell and gene therapy of diabetes with more efficient function analysis and overall therapy services.

Cell Therapy of T1DM

Cell therapy mainly includes tumor cell immunotherapy and stem cell therapy. Islet cells can be generated from human pluripotent stem cells (hPSC) including induced pluripotent stem cell (iPSC) cells or embryonic stem cells (ESC) for the treatment of diabetes. It is transplanted into the body through special transplantation techniques to replace those normal or abnormally dead β-cells.

Mechanism of the suppressive action of T cell lymphocytes in T1DMMechanism of the suppressive action of T cell lymphocytes in T1DM (Ben-skowronek, I.; et al. International Journal of Molecular Sciences, 2021)

Gene Therapy of T1DM

Two HLA class II haplotypes involved in antigen presentation, HLA-DR and HLA-DQ, are linked to approximately 50% of disease heritability. In T1DM, insulin secreting β-cells are destroyed by inflammatory cells, so gene therapy for T1DM is based on β-cells were the best target. It can prolong survival of functional β-cells and long-term normal blood glucose level. 

Our Services

Cell and gene therapy research provides more options for diabetes treatment options. With the goal of scientific research of diabetes, Ace Metabolism can provide a full set of services including stem cell therapy development service and gene therapy development service schemes. Our services include but not limited to the followings. 

  • Target Prediction and Verification
    The mutation sites that lead to disease phenotypes are obtained through the Whole Genome Resequencing, and then relevant cell or animal models are constructed for verification.
  • Stem Cell Therapy Development Service for T1DM
    Providing research strategies for generating islet-like cells from pluripotent stem cells including induced pluripotent stem cells.
  • Gene Therapy Development Service for T1DM
    Providing a set of services of gene therapy schemes including gene editing for gene therapy, mRNA-based gene therapy development and vectors for gene therapy.

Features of Our Services

Highly CustomizableHighly Customizable

One-stop ServicesOne-stop Services

High QualityHigh Quality

Professional TeamProfessional Team

Ace Metabolism offers cost-effect and high-quality research services related to T1DM gene therapy for our clients worldwide. Our assays are developed and processed with the highest standard and the results are delivered on time without compromising quality. Please feel free to contact us.

Reference

  1. Ben-skowronek, I.; et al. Potential Therapeutic Application of Regulatory T Cells in Diabetes Mellitus Type 1. International Journal of Molecular Sciences. 2021, 23(1), 390.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
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